Kyler Murray threw four touchdowns, Kennedy Brooks and Trey Sermon both had 100-yard rushing games and ninth-ranked Oklahoma won 52-27 at TCU.
The Sooners rebounded from their only loss, which came at Texas two weeks ago in their last game. They beat TCU for the third time in 11 months.
Oklahoma won its 18th consecutive true road game, never trailing after scoring touchdowns on each of its first four drives.